Dorsal raphe serotonergic neurons promote arousal from isoflurane anesthesia
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چکیده
منابع مشابه
Presynaptic Partners of Dorsal Raphe Serotonergic and GABAergic Neurons
The serotonin system powerfully modulates physiology and behavior in health and disease, yet the circuit mechanisms underlying serotonin neuron activity are poorly understood. The major source of forebrain serotonergic innervation is from the dorsal raphe nucleus (DR), which contains both serotonin and GABA neurons. Using viral tracing combined with electrophysiology, we found that GABA and ser...
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The serotonergic raphe nuclei of the midbrain are principal centers from which serotonin neurons project to innervate cortical and sub-cortical structures. The dorsal raphe nuclei receive light input from the circadian visual system and indirect input from the biological clock nuclei. Dysregulation of serotonin neurotransmission is implicated in neurobehavioral disorders, such as depression and...
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The dorsal raphe nucleus (DRN) projects serotonergic axons throughout the brain and is involved in a variety of physiological functions. However, it also includes a large population of cells that contain other neurotransmitters. To clarify the physiological and pharmacological differences between the serotonergic and non-serotonergic neurons of the DRN, their postsynaptic responses to 5hydroxyt...
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1 2 3 Nicotinic Excitation of Serotonergic Projections from Dorsal Raphe 4 to the Nucleus Accumbens 5 6 7 Running Head: Nicotinic receptors in the Dorsal Raphe Nucleus 8 9 Ben Chang, Claire Daniele, Keith Gallagher, Michelle Madonia, Robert D. 10 Mitchum, Lindy Barrett, Paul Vezina , & Daniel S. McGehee. 11 Department of Anesthesia & Critical Care, Committee on Neurobiology, Department 12 of Ps...
متن کاملSubcutaneous administration of nicotine changes dorsal raphe serotonergic neurons discharge rate during REM sleep.
In the present study nicotine (0.1 mg/kg, s.c.) increased discharge rate of putative dorsal raphe (DRN) serotonergic neurons of behaving rats during REM sleep (362.61%), without any significant change during waking and non-REM sleep. Since serotonergic DRN neurons gate PGO onset, these results suggest that nicotine-induced suppression of PGO spikes during REM sleep previously reported is achiev...
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ژورنال
عنوان ژورنال: CNS Neuroscience & Therapeutics
سال: 2021
ISSN: 1755-5930,1755-5949
DOI: 10.1111/cns.13656